Tubulin

Tubulin is the protein which makes up microtubules. Microtubules are made up of an αβ-tubulin dimer consisting of the two subunitss (α/alpha and β/&beta). Each of these subunits has three domains. γ-tubulin is important in the nucleation and polar orientation of microtubule.

Pharmacology

Tubulins are targets for anticancer drugs like taxol. The anti-gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decreasing inflammation.