Santa CruzSanta Cruz, Spanish & Portuguese for "Holy Cross", is the name of several cities, regions, and other geographical features around the world:
- Santa Cruz, Argentina
- Santa Cruz Province, Argentina
- Santa Cruz, Bolivia
- Santa Cruz Department, Bolivia
- Santa Cruz, Espirito Santo, Brazil
- Santa Cruz, Paraíba, Brazil
- Santa Cruz, Pernambuco, Brazil
- Santa Cruz, Rio Grande do Norte, Brazil
- Santa Cruz, Cape Verde
- Isla Santa Cruz, Galápagos Islands, Ecuador
- Santa Cruz, a suburb of Mumbai, India
- Santa Cruz, Goa, a town in the state of Goa, India
- Santa Cruz, Laguna, Philippines
- Santa Cruz, Almodôvar, Portugal
- Santa Cruz del Valle de los Caídos, Madrid, Spain
- Santa Cruz de Tenerife, a city in the Canary Islands, Spain
- Santa Cruz de Tenerife Province, Spain
- Santa Cruz de La Palma, Spain
- Santa Cruz County, Arizona, United States
- Santa Cruz, California, United States
- Santa Cruz County, California, United States
- Santa Cruz Island, California, United States
- Santa Cruz Mountains, California, United States
- Santa Cruz, Texas, United States
Santa Cruz is the name of a Brazilian soccer team:
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